Marana Mrudangam is action drama based movie in which, Johny (Chiranjeevi) runs a small time restaurant with his partner (Nagendra Babu). One fine day he helps two women ( Radha & Suhasini), stuck with their broken car and gives them a drive.
Jwala (suhasini) succeeds in an interview, by remembering Johny's words and gets a job as nurse in an hospital.Johny and his partner also help Radha to get a job by blocking the competitor.
One day, Naga babu discovers cocaine in an egg in his kitchen and they start investigating the source of this egg.
They discover this to be from Gollapudi's store. This unfolds the links between a seemingly businessman, gollapudi and underworld Don, Suresh Oberoi. They also offer jobs to unemployed and use them to sell their body parts.
Jwala's unemployed brother prasad gets into their trap and leaves home.Jwala reaches Johny for help to talk to her brother.Johny discovers that the phone number given to contact her brother is in the same city and starts exploring into this.
Meanwhile Radha lodges a complaint against gollapudi and his son, sudhakar about their dark secrets. Salim (Ranjeeth), a left hand of suresh oberoi, disguises himself as a police and asks radha to come with him for enquiry. Rest of the story how Jhony deals all these problems.