The film starts off with a search operation by Dev (Saurabh Shukla) and Nikki (Mugdha Godse). This brother-sister duo are in search of Nikki's 'non-ambitious but honest' husband Purushottam Tripathi (Vinay Pathak), who leaves the house after a tiff with his nagging (but loveable) wife Nikki. While on one hand, Nikki's relatives help to reconcile her relationship with Purushottam, on the other hand, the couple's common friend lays his bets on them getting divorced. Caught in a whirlpool of relatives, friends and emotional turmoil, Purushottam lands up in a gambling den, where he drinks heavily and wins not just the money but also the company of a 'working woman' prostitute Rubina (Raima Sen). Despite all her attempts to seduce him, the 'patni-vratha' Purushottam refuses to give in to her advances. Seeing a 'truthful human' in her, he starts staying with her, but without any intimacy between them. On a professional front too, his life is in turmoil as his book 'Ek Thehri Si Zindagi' fails to find any publisher, which further adds to his frustration. One day, when Purushottam is totally out of control emotionally, he again lands up at the same gambling den. Lady Luck favors him to the core and he makes a killing, so much so that he even defeats the owner of the gambling den 'in his own game'. He, then, hands over all the winnings to Rubina asking her to fund her brother's education. The next day, a series of incidents happen in quick succession that puts everyone including Purushottam in a tizzy. While on one hand, Purushottam gets kidnapped in broad daylight, on the other hand, someone renames his book from 'Ek Thehri Si Zindagi' to 'Ek Tharki Si Zindagi', which lands up being a Bestseller' in no time of its publishing. Who are the people responsible for Purushottam's kidnapping and what are their motives, who is responsible for the renaming of the book, do Purushottam and his wife ever make peace with each other or do they land up divorcing each other is what forms the rest of the story.