Madhoshi is based on a young girl Anu ( Bipasha Bashu ), she belongs to a well to do family. Her sister and brother in law were killed in the unfortunate attacks on the World Trade Center, the impact of this traumatic incidence hit her very hard.

Two years later her life came to normalcy and she met Arpit ( Priyanshu ) who a renowned owner of an ad agency. Soon she fell in love with her and they were slated to marry within few months.

One day in a dramatic incident she met Aman ( John Abraham ), who works for the Anti-Terrorist organization, inspired by his heroic lifestyle she fell for her and on the day of her marriage with Arpit she snapped her wrist ion protest of marriage. The doctors diagnosed her being suffering from schizophrenia. Soon all found out that there was no one like Aman, it was just hallucination. 

One day a man who looks like Aman comes to her parents and told them that he is ready to help their daughter by marrying her. Just before the marriage he revealed that he was Arpit and has undergone plastic surgery to help Anu become normal.