Nene shabana' is a story of young college student Shabana Khan (Taapsee Pannu). Shabana's best friend Jai (Taher Shabbir Mithaiwala) loves her and proposes her on a date. While returning back Shabana and Jai are eve teased by some hooligans, which leads to a fight between them and in that fight Jai gets killed. Shabana tries her best to get justice, but fails miserably. At that moment she receives a call from Ranvir (Manoj Bajpayee), who claims to be a part of a powerful government based organization and promises to help Shabana find Jai's killers. In order to share the information, Ranvir also strikes a deal with Shabana, where she has to join their organization. Shabana agrees and thus starts the making of a spy.