'Missing On A Weekend' is a story of police inspector Ali Ansari (Pawan Malhotra), who has been assigned to investigate a murder of a young tourist in the resort of Goa. Ali and his colleague Ajay (Dishank Arora) find Laksh (Karan Harihran) in an unconscious state and believe that he might be able to solve the murder case. But before Ali and Ajay could start their investigation, they come to know that Laksh is going through a temporary memory loss, due to which he does not remember anything related to the whole incident. Thus, Ali starts his investigation right from the scratch leading to something more than a simple murder.