Vunnadhi Okate Zindagi begins with the scenes depicting the friendship Abhiram (Ram) shares with his friend Vasu (Sree Vishnu), and moves on to the present where Abhi is shown as a guy owning a coffee shop in Milan. Cut to the flashback and Abhi is a college goer, who falls in love with house surgeon Maha (Anupama Parameswaran), and he motivates her in singing. In a twist of fate comes and end to his love story, with the arrival of  Vasu impacting their friendship. Back to present, now Abhiram decides to come to India for a friend's wedding, where he gets to meet wedding planner Meghna alias Maggie (Lavanya Tripathi) who instantly connects with Abhiram. As Vasu also arrives for the wedding, whether the friends Abhiram and Vasu reunite, and was Abhi Lucky in Love atleast the second time is what Vunnadhi Okkate Zindagi is all about.