Harishkumar Satishkumar Patel (Sunil Malhotra) is a geeky student from a small village in Gujarat, India who is attending the University of Houston, while living with his uncle (his father's best friend). His uncle, Dr. Bakshi, has an American-born son who is Hari's age, Mohan Bakshi (Kal Penn). Mohan, known as Mo, is a very popular Indian student at UH. He shows Hari around the college but then stays away from him because of Hari's nerdy ways.

Hari, meanwhile, is overly excited because of an astrological prediction that was made by a holy man. The famous astrologer told Hari that he'll meet his Sapno Ki Raani (the girl of his dreams) in America and her name will begin with alphabet "P". Hari then meets Priya (Tina Cherian), a Malayali studying fashion, and falls in love with her. In the meanwhile, Mo falls in love with Janvi Valia (Serena Varghese), a Punjabi girl, but things don't go as planned when Mo invites Janvi to a party. In the film's conclusion, Mo learns important things about his culture, and Hari overcomes his challenges. This film is primarily a comedic portrayal of young Indian Americans going through life.