Subramanyam for Sale is a tale of family, love and responsibility, the story is about moneymaker Subramanyam (Sai Dharam Tej). He is the beloved son of (Naresh) and goes to any extent to earn few dollars to clear his debts. On the other hand, Seeta (Regina)’s father (Suman Talwar) wants to get her married to a relative much against her will. And she runs away from home, with the help of Biyyum Bucchi (Rao Ramesh). That’s when Subramanyam meets up with Seeta (Regina) and helps to get over her crisis in America. Soon after that Geeta (Tejeswini) forces Seeta to return back home for her marriage and she asks Subrahmanyam to feign as her husband and go to her place. That’s when Subrahmanyam pens to solve family problem of Seeta, instead he sees that there are more issues to be settled, thanks to NRI Rajashekahar (Naga Babu). In this situation, his life takes a forceful turn as Govind (Ajay) associates start following him. In these situations, one can easily predict the outcome, when the boy is smothered between two families.