Chandamama Lo Amrutham Amrutha Rao(Srinvas Avasarla) and Anjaneyulu(Harish) are two best friends, who get separated because of a foolish condition laid by Amrutha Rao’s father in law. Both the friends set out on their own way, and become rich and successful businessmen by running their respective hotel industries. This is also the time when the government starts tourist visits to the space. Twist in the tale comes when their old house owner Appaji(Sivanarayana) comes up with an unique idea to take the two friends to space, and make them open restaurant business there. Both the friends fall for the trap, and sell their entire property and end up on space along with a few others. Rest of the story is as to what happens to the entire gang, when they land up in space..