Sitapathi Chalo Tirupathi is a comedy based drama flick. Sitapathi (Rajendra Prasad) and Sita (Aishwarya) are in love with each other. But Sita's father Pichayya (Kota Srinivas Rao) is totally a money minded person. He wants his daughter to get married to a rich man. Sitapathi's grandmother and his father forces him to go to tirupathi and earn money so that he can marry Sita. In Tirupathi, Sitapathi meets Magatayaru (Vani Vishwanath) who falls in love with him. Will Sitapathi be able to earn money and marry Sita or will he fall for Mangatayaru, forms the rest of the story.